Il Cannabidiolo (CBD), uno dei maggiori componenti della Cannabis, ha dimostrato di possedere potenti proprietà anti-infiammatorie e anti-ansiogene, senza effetti psicotropi. è stata, però, osservata una curva a campana nella risposta alle dosi che ne può limitare l'efficacia clinica.

Uno studio, condotto da Ruth Gallily, Zhannah Yekhtin e Lumír Ondřej Hanuš della Hadassah Medical school di Gerusalemme, si propone di analizzare l'attività anti-infiammatoria e anti-dolorifica, nelle cavie, dell'estratto standardizzato di una varietà di Cannabis ad alto tenore di CBD.

I risultati hanno evidenziato una chiara correlazione, direttamente proporzionale, tra la dose di farmaco e la risposta anti-infiammatoria e anti-dolorifica, fornendo un'importante punto a favore dell'utilizzo clinico dell'estratto vegetale di Cannabis contro l'estratto di CBD isolato.

Overcoming the Bell-Shaped Dose-Response of Cannabidiol by UsingCannabisExtract Enriched in Cannabidiol

Authors

Ruth Gallily¹,Zhannah Yekhtin¹,Lumír Ondřej Hanuš²

Affiliations

¹The Lautenberg Center for General and Tumor Immunology, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.
²Department of Medicinal and Natural Products, Institute for Drug Research, The Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.

Our findings that CBD in the presence of other plant constituents improve the dose-response are supported by some recent reports showing that CBD in a standardized Cannabis sativa extract is more potent or efficacious than pure CBD. These research groups studied the anti-proliferative effect of CBD on tumor cells and the inhibitory effect of CBD on bladder contractility. The higher efficiency of plant extract might be explained by additive or synergistic interactions between CBD and minor phytocannabinoids or non-cannabinoids presented in the extracts. Other phytocannabinoids, including Tetrahydrocannabivarin, Cannabigerol and

Cannabichromene, exert additional effects of therapeutic interest. A lot of research has been made to isolate and characterize isolated single constituents of traditional herbal medicine to find their rationale for therapeutic uses. However, our data together with those of others provide legitimation to introduce a new generation of phytopharmaceuticals to treat diseases that have hitherto been treated using synthetic drugs alone. The therapeutic synergy observed with plant extracts results in the requirement for a lower amount of active components,with consequent reduced adverse effects.

In conclusion, we recommend standardized plant extract of the Cannabis clone 202 for treatment of various inflammatory conditions.

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